Est. Read Time: ~Keurig Brew-Time
prettyPhoto is a great gallery with many options to customize different elements. It works cross browser and handles different setups such as images, slideshows, Flash, YouTube, Vimeo, Quicktime, external site iframes, inline content and AJAX content.
There are options for multiple galleries using relative naming and grouped thumbnails in the pop-up making navigating through images quick and easy. It also includes integrated social buttons for Facebook and Twitter if desired, title and description tags, image count.
The developer includes great documentation, tutorials on different setups, FAQs and support forums.